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Image Search Results
Journal: Neuropsychopharmacology
Article Title: The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy
doi: 10.1038/npp.2010.195
Figure Lengend Snippet: Kinase profiling reveals activity of clozapine only at checkpoint kinase 2 (ChK2). (a) Shown are results from a kinase profile performed with a Caliper microfluidics-based screening platform (part no. 760373) that comprises 20 different purified kinases. Clozapine (10 μM) was tested against all the kinases shown above and data are presented as % inhibition of kinase activity. (b) Dose-response studies with clozapine and the nonspecific kinase inhibitor staurosporine at Chk2. Data represent mean±error of N=3 separate determinations. EC50 values determined using GraphPad Prizm.
Article Snippet: EC 50 values determined using
Techniques: Activity Assay, Purification, Inhibition